Common cold season is back, which has people wondering why we catch the same virus, year after year. Why don’t we ever develop immunity against the common cold Professor Pierre Talbot at INRS has known about the incredible variability of coronaviruses for some time. They’re responsible for the common cold as well as many other infections, including neurological diseases. Along with his research associate Marc Desforges, Professor Talbot worked on a study recently published in Nature Communications about the ways in which coronaviruses adapt and evolve, becoming ever more effective at infecting hosts without being defeated by the immune system.
The small, spiky spheres, the coronaviruses are closely monitored by public health agencies, since they’re able to be transmitted between species and some have a high potential mortality rate. Both SARS and MERS are caused by coronaviruses. Their ability to adapt to new environments seems due in part to the spikes on the surface of the virus–more specifically, a small, strategic part of the proteins that form those spikes.
The spikes are made up of S proteins (S for spike). A specific part of the spike seems to allow the virus to attach itself to host cells. The spike’s RBD (receptor binding domain), which initiates the interaction between cell and virus, is essential for infection. But RBDs are targeted by antibodies that neutralize the virus and allow the immune system to flush it out of the host’s system.
