Cell therapy is a new approach to tackle these difficult forms of cancer. The first such drug, Kymriah, developed by Novartis, was approved by the US Food and Drug Administration earlier this year for the treatment of lymphoblastic leukemia in cases where other types of treatment fail. The therapy involves extracting millions of a patient’s T-cells and genetically modifying them to destroy malignant cancer cells before returning them.
The modification introduces a chimeric antigen receptor that targets a specific protein molecule found on the surface of cancer cells—CD19—in leukemia and lymphoma. But even patients who have undergone this therapy suffer recurrences. Now, researchers from Stanford University School of Medicine and the National Cancer Institute designed a new CAR T-cell therapy that targets a different surface molecule, CD22.
“This is the first time that we’ve seen response rates anything like we achieved when we were first testing the CD19 CAR T therapy,” says Stanford’s Crystal Mackall, the senior author of the study, in a press release.
The Phase 1 trial enrolled 21 children and young adults (ages seven to 30) with B-cell acute lymphoblastic leukemia who had relapsed or not responded to previous treatment. Fifteen of them had also undergone CD19-targeted cell therapy without significant improvement. The patients were administered varying doses of the new, anti-CD22 CAR T-cell therapy.